DU-126891 hydrochloride
7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one hydrochloride
CAS: 269718-83-4
Molecular Formula: C12H16ClN3O2
DU-126891 hydrochloride - Names and Identifiers
DU-126891 hydrochloride - Physico-chemical Properties
| Molecular Formula | C12H16ClN3O2 |
| Molar Mass | 269.72734 |
| Solubility | DMSO : 150 mg/mL (556.11 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Use | Pardoprunox (SLV-308) hydrochloride are dopamine receptor D2, D3 partial agonist and 5-HT1A agonist with pEC50 of 8, 9.2 and 6.3 respectively. |
| In vitro study | Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC 50 = 8.0 and pA 2 =8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC 50 =9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA 2 =9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC 50 =6.3). |
DU-126891 hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.707 ml | 18.537 ml | 37.074 ml |
| 5 mM | 0.741 ml | 3.707 ml | 7.415 ml |
| 10 mM | 0.371 ml | 1.854 ml | 3.707 ml |
| 5 mM | 0.074 ml | 0.371 ml | 0.741 ml |
Last Update：2024-01-02 23:10:35
DU-126891 hydrochloride - Reference Information
| biological activity | pardoplunox hydrozolide (DU-126891, SME-308) is a potent partial agonist of the dopamine D2 receptor, corresponding to a pEC50 value of 8.0, which is also a partial agonist that induces [35S] gtpγs binding, corresponding to a pEC50 value of 9.2, and an agonist of serotonin 5-HT1A receptor, the pEC50 value was 6.3. |
| Target | Value |
| [ (Cell-free assay) | 9.2(pEC50) |
| D2 receptor (Cell-free assay) | 8.0(pEC50) |
| 5-HT1A receptor (Cell-free assay) | 6.3(pEC50) |
Last Update：2024-04-09 21:54:55
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Product Name: 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one hydrochloride Visit Supplier Webpage Request for quotationCAS: 269718-83-4
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Pardoprunox Hydrochloride Visit Supplier Webpage Request for quotationCAS: 269718-83-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one hydrochloride Visit Supplier Webpage Request for quotationCAS: 269718-83-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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